Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Clinical effect of platelet-rich fibrin in combination with narrow-band ultraviolet B treatment in patients with small area deep burn wounds

Jianhua Yang¹, Xue Li², Hao Liu³, Xiaodan Zhao¹

¹Imaging Center, Shandong Provincial Third Hospital, Shandong University, Shandong, China; ²Department of Cosmetic Surgery, Jinan Airong Plastic and Cosmetic Hospital, Shandong, China; ³Department of Burn Reconstructive Surgery, The 960th Hospital of the PLA, Jinan, 250000 Shandong, China.

For correspondence:- Xiaodan Zhao Email: feixie11118383927@163.com

Accepted: 26 June 2023 Published: 31 July 2023

Citation: Yang J, Li X, Liu H, Zhao X. Clinical effect of platelet-rich fibrin in combination with narrow-band ultraviolet B treatment in patients with small area deep burn wounds. Trop J Pharm Res 2023; 22(7):1451-1456 doi: 10.4314/tjpr.v22i7.13

© 2023 The authors.
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Abstract

Purpose: To investigate the influence of the combined use of platelet-rich fibrin and narrow-band UV B (NB-UVB) treatment on small-area deep burn wounds in patients.

Methods: A total of 86 patients with small area deep burn wounds were assigned to control and study groups (n = 43/group). The control patients received routine drugs in combination with NB-UVB, while the study group was administered a combination of platelet-rich fibrin and NB-UVB therapy. Clinical efficacy indices were.

Results: In the study group, the pre and post-treatment serum levels of TNF-α were 222.75 ± 4.86 and 65.42 ± 5.33 ng/L, while those in control group were 221.45 ± 6.84 and 114.68 ± 2.53 ng/L, respectively. The study group serum concentrations of IL-8 at pre- and post-treatment were 120.75 ± 4.53 ng/L and 45.39 ± 8.26 ng/L, while the control group values were 122.38 ± 2.65 and 79.52 ± 2.34 ng/L, respectively. After treatment, the serum levels of TNF-α and IL-8 were significantly down-regulated in both groups, relative to pre-treatment values, with lower levels in the study group (p < 0.001). Wound healing time and frequency of dressing change in the study group were 20.6 ± 3.6 days and 7.1 ± 2.5 times, respectively, which were significantly lower than the corresponding control group values of 40.3 ± 10.7 days and 20.5 ± 5.6 times (p < 0.001). There was a significantly higher incidence of scars in the control group than in study group (p < 0.05).

Conclusion: Combined use of platelet-rich fibrin and NB-UVB in the treatment of small area deep burn wounds lowers the serum levels of inflammatory factors. However, the combined therapy should be subjected to further clinical trials prior to application in clinical practice.

Keywords: Small-area deep burn wounds, Platelet-rich fibrin, Narrow-band ultraviolet B (NB-UVB)